. Wow! Vectras brag is that it repels and kills fleas, five kinds of ticks, flies, mosquitoes, and mites; however, its use is not worth its risk. Thank you so much for all your hard work and care given to writing this very informative and extremely important study greatly appreciate it , I would like to thank you for your very thorough but get to the point info of all these parasitic treatments We have a rough Collie I could not find any info on safe treatments without wading through a river of muck. Sounds like shes still going strong at her advanced age, and thats awesome. We have an MDR1 heterozygous Aussie and this was the best breakdown of the meds we found. Since I live in Florida, Revolution is not the best choice for me as it only targets the dog tick. Are you referring to Advantage Multi, Advantage II, or a different product I didnt cover in the article? You can also reach me through the contact form here on the website. Although it would be very hard to determine exactly which component of a combination medication your Collie is reacting to, your girl might be less likely to have a reaction to Interceptor (regular, not Plus), as it only has one active ingredient as opposed to the two active ingredients in Sentinel. Any dog can have a sensitivity to a certain substance and should always be monitored for reactions after a new product has been administered. What an awesome article. . It is the first drug that combined three active ingredients - sarolaner, moxidectin, and pyrantel. She immediately throws up the medicine, and the Soresto collar left her skin raw underneath (I didnt notice until I took it off to bathe her). The recently introduced isoxazoline, lotilaner (Credelio) for dogs falls into this same class. Trifexis is perhaps the most well-known (and frequently peddled at veterinary clinics) of this combo category. It makes me nervous since I have seen/read plenty of negative things about bravecto and Im also worried to combine bravecto with interceptor. We sometimes see a Smooth Collie named Frank at our local dog park, and Ive been pretty impressed with him. I do remember her cowering and rubbing her back against her crate after we administered anything topical! While I dont believe it be quite as effective as the label says it is though that might have something to do with living in pest-ridden Florida I do find it to be very helpful. If youre looking for something that will repel parasites, a product such as K9 Advantix II may make a good alternative. Astfel, produsul Simparica Trio Caini (40.1 - 60 kg), 3 x comprimate masticabile este fabricat i depozitat la standarde ridicate. It comes in pill form, starts working within 30 minutes, and will kill all the fleas on a dog within 4 hours. I was bummed to read its the safest since I dont want him to have it every again (a little off balance shortly after and salivating) but later he had an episode with fixed eyes, stuck in a strange position, stiff muscles, blind, he had a heart rate half of what it should have been and a head tremor. I hate to use anything, but also tired of keeping my dogs in a bubble. Emily is an avid writer, blogger, and Collie lover who collects and posts stories about Collies from around the world. The topical medicines seem to work best with her, but dont do much to keep the tics at bay. While my pain levels went down, I noticed that my heart rate went up! Thousands of dogs have experienced serious adverse reactions after taking . This organic powder is great for a variety of uses. Be prepared to answer questions about whether your dog had a previous history with seizures, has any drug sensitivities, if anything else could possibly have triggered a seizure, and if she has had any seizures since the collar was removed. Super useful research. Fleas were treated with effifax, active ingredient fipronil. Like Nexgard, Simparica needs to . Hi Emily, Shes been a red hot mess and Im not convinced Simparica isnt the cause(stomach issues, hyper activity(I raised a border so ready for energy but this is frenetic) and not sleeping more then 30- 40 minutes at a time. I have two Rough Collies who are MDR1 carriers and an Aussie mix, so I have a vested interest in everything Ive researched. Of all the products you mentioned, I would prefer to try K 9 Advantix since it both repels and kills. Before I got them home, they went into comas. You can even scatter some on your dogs bed. Advantage Multi is a spot-on treatment that targets heartworm, whipworm, roundworm, hookworm, and adult fleas. Simparica Trio treats and protects against harmful parasites. Also, it is not recommended for use with other medications. Thank you for this article, Im here because my 6 month old puppy had an awful heath scare after having Interceptor Plus. (Which made him feel really sick.) 2022 Collie Chatter. for, I think its brown ticks. To help with this, the product can be applied in more than one line between the neck and shoulder blades. . Wondercide sounds like an excellent place to start as far as flea and tick prevention, and I hope it will be effective against mosquitoes, too. If youre concerned about a possible hormonal imbalance being triggered by Effifax, it might be worth looking into an alternate flea control product that does not contain Fipronil. Im happy to hear you found it helpful! For my Aussie mix, Ive had success using Advantix II. With complaints rolling in, the company made adjustments to the Ivermectin content in their product, and Heartgard is now advertised to be safe at the recommended dosage. But according to Dr. Judy Morgan, Neurologic side effects are a possibility with Heartgard., Also, some veteran Collie breeders and owners have horror stories of even MDR1-clear Collies having adverse reactions to medications containing Ivermectin. Now that this information has come out, I can no longer officially recommend Seresto collars since many Collies have sensitivity issues even if they dont have MDR1. , Thanks for the reply! It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. After 24 hours, it is considered waterproof and a bath, while alleviating some effects, will not offer as much relief. Simparica TRIO requires a prescription from your veterinarian. If this gene is mutated, it will create a defective protein, and consequently, drugs will remain and build up in the brain to toxic levels. I was using Seresto collars and am on the hunt for something else. , I use Advecta 3 because it prevents and kills I have been in the dog Bussiness for over 26 years and used to use frontline bit past few years switched because frontline doesnt prevent .I never had a problem with advecta 3 and hope its safe, As this is a Collie blog and I assume the majority of people who read this post have a Collie, Im just hesitant to recommend it since many Collies have issues with sensitive skin even if theyre clear of MDR1. Thank you for the useful information which is a little easier (clearer) to understand than most. Get new post updates in monthly email newsletters. The product was well tolerated in dogs with a deficient multidrug-resistance-protein 1 (MDR1 -/-). Happy to help! I recently saw the USA Today headline (I get notifications on my phone) about Seresto collars and made a mental note to read it later and update this article if need be then promptly forgot about it! Thanks for your informative article. A negative heartworm test is crucial prior to beginning administration of diethylcarbamazine. GestorVet es el futuro de la gestin veterinaria. If you can, its always a good idea to consult with a vet who is knowledgeable about MDR1 and Collies. Thank you, and hello to Nola and Otis! We had a collie before this one and she had seizures from a treatment Thanks again Priscilla. They were extremely helpful people. Should I give them Trifexis or Sentinel Spectrum? All Rights Reserved. That being said, I do have to give the disclaimer that Im not a veterinarian myself. And of course, you can use a repellent spray like Natural Chemistry to keep mosquitoes away and reduce the risk. Given your knowledge, would you suggest Credelio vs. K9 Advantix II (if tolerated) ? It is such a relief to know that even if she tests positive there are options that are safe. Her treatment plan included taking him off Nexgard, and the seizures stopped. So tick protection is also a must for us. Natural Chemistry claims to kill on contact and to be safe for puppies. At least once a week or before we go walking down woodland trails, I also take the precaution to spray my dogs legs and lower body (and my shoes) with Natures Best or Natural Chemistry flea and tick repellent. Unfortunately, both my Collies and to a lesser extent my Aussie mix have some skin sensitivities: so K9 Advantix II and Seresto, while very effective, would most likely cause them skin irritation. However, I have to state the disclaimer that even parasite protection products officially labeled safe from an MDR1 standpoint should really be designated safe-ish. Most of these products are chemical compounds, and as such have more potential to cause a reaction than just, well, water. I myself have successfully used both on my 2 Collies and my Aussie mix with no ill effects. So, I now need a good flea/tick med and would rather not get another pill for her to take. But of course, do talk to your vet and see what they know. Turns out it is also used for the treatment and prevention of roundworms and lungworm nemotodes in dogs, according to Vet Shop Max. SIMPARICA TRIO killed fleas before they could lay eggs for 35 days. Hi Emily, do you know if panacure is a safe wormer? There werent as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. Simparica Trio prevented microfilaremia in all dogs and was highly effective (97.2%) and significantly better than either Heartgard Plus (8.5%) or Interceptor Plus (35.9%) in preventing the development of the ZoeLA ML-resistant heartworm strain when administered for six consecutive months in this co Sarolaner is an . No treatment-related clinical signs were observed. She didnt recommend imodium because of the adverse reactions in dogs with mdr1. However, not all MLs are created equal, and some are safer than others. The login page will open in a new tab. Bottom line is that Simparica will probably be fine for your dog, but there is a slight risk that it wont. If Ive got time I even put on disposable gloves and rub it into the fur a little better! The active ingredients of SimpleGuard 3 are the same as Vectra 3D: dinotefuran, pyriproxifen, and permethrin. If you think about it, come back here and let me and other readers know what worked best for you! You should still keep an eye on your pet when introducing new organic products. One observation: You mention that Credelio has fewer reported seizures (6 in as many months) than other drugs in the isoxazaline class. PRUEBA GRATUITA FUNCIONES. I did some digging, and from what Ive read it sounds like just one report would be considered anecdotal and would not be considered evidence that Seresto could cause seizures, but if there are 2 or more reports then the company might be obliged by the EPA to add a potential seizure warning to its label or possibly to do more clinical safety research. However, in such sensitive breeds (which may include, but not necessarily limited to, Collies and related breeds), the recommended dose should be strictly observed. No one knows yet why some dogs react to isoxazolines like Simparica and others dont, and theres no way to know until its tested on an animal. And safe travels to you and Lola in the future. Based on your recommendations, I will not use Vectra. Sarolaner had been approved in 2016 to treat flea and ticks, moxidectin . As far as which flea and tick protection would be safest for a puppy, some of my top picks are Capstar (for instant relief, not necessarily long-term use), a natural oil spray like Natural Chemistry or Wondericide, or something not very harsh like Frontline Plus. Thank you for the positive feedback. (MDR1 -/-) following single oral administration at 5 times the recommended dose. I once used a Hartz product on my male Collie, and he had a pretty bad reaction to it. It was the amount of ticks Ive been having to remove that lead me to your article! We often go on walks in the woods. Personally, my Roughs have sensitive skin plus I have a household cat, so Id try Frontline Gold first. Simparica TRIO is a monthly chew with triple protection against the three biggest threats facing our dogs today - fleas and ticks, intestinal worms and deadl. Dogs with the MDR1 genetic mutation can become very ill or die if given certain medications. Hi, Thank you for this helpful article. Simparica Trio has the same main ingredient as regular Simparica, plus two added ingredients. Personally I use Frontline Plus and supplement weekly with a Natural Chemistry spray as a repellent, but I understand that might not be ideal for everyone depending on their situations. These three are listed as a new group of drugs called Isoxazolines, and are neurotoxins. (The Environmental Protection Agency is responsible for approving external flea and tick products.) What are your thoughts on that? My personal vet is knowledgeable of the MDR1 gene mutation (now also referred to as the ABCB1 mutation), and he recommended Interceptor to me for my mutant/normal Collies. 5 A dog's reaction to flea bites may vary from sores and inflammation to hair loss. (Just bear in mind that Preventic contains amitraz, which is toxic to cats.). They both have tolerated Bravecto very well.no noticeable side effects. She was obviously in discomfort. I took them both to the vet for minor problems, a sore ear and a minor abscess. We took her to a vet who is very experienced with collies (she helps with a rescue) and has assured me that Simpirica Trio is safe. The vet is really no help. This monthly chewable is recommended for 8 weeks and older dogs, weighing 2.8 lbs or more. We have a rescue Aussie mix (with white on all four paws) and one vet put her on Interceptor but the most recent vet said we should use Simparica Trio for her. Those are both still very effective products, but have fewer horrror stories of terrible skin reactions. Please let me know how the Wondercide works for you! It was winter. Im glad you found it helpful. Positive feedback keeps me writing! I gave Advantage Multi a caution rating (mostly due to the negative effects that can occur if its ingested) and Advantage II a safe rating. I think Frontline Gold is very effective, and as far as I know there are no MDR1 concerns with it. He said he himself uses Seresto collars on his Australian Shepherds, but that in his experience the collars tend to last 6 months for his fluffballs, not 8. My dog (6 years old) has been using monthly Simparica since I got him. Of course, I do have to state the disclaimer that theres no guarantee with any product that it wont cause a reaction, but it sounds like youre doing a good job of monitoring your girl after giving her anything. According to Dr. Jean Dodds of Hemopet, researchers and veterinarians thus far cannot point to breed characteristics, age group, drug interactions or genetic mutations as contributing factors to the latest findings that prompted the FDA warning. In other words, the reported adverse reactions to Bravecto had nothing to do with whether or not a dog had MDR1. Basically, while the FDA has not pulled these drugs from the market, it has asked the product manufacturers to add precautions to their labels while it continues to monitor information submitted by veterinarians, the companies themselves, and individual product users. Have you had any issues with Seresto? Thats what Im doing for my most recent Collie. Dogs with the mutation lack a protein (P-glycoprotein) which is responsible for pumping the drugs from the brain. Good luck with the puppies, and I hope they get healthy soon. Interceptor is the go-to heartworm preventive for many Collie parents. Fleas start to bite within 5 minutes. Eur. If youre someone who lives in a tick-prone area or likes to take your dogs on woodland rambles (like me), this is a letdown. Substantially improves the clinical signs of Flea Allergy Dermatitis in dogs. Simparica. Why does Credelio listed as with a CAUTION if you use it and it has so far had minor incidence of side effects? I am currently fostering 3 rescued puppy mill border collie females with sarcoptic mange. Somewhere I read that its good for 4 kinds. As with everything else, monitor your dog for symptoms. Simparica: The manufacturer of Simparica has tested the product for safety in dogs with the MDR1 . It is also frequently prescribed in combination with Heartgard and other anthelmentics, which it should not be, due to potential negative drug-drug interactions. Is it safe to give an occasional one to him even though hes on Bravecto 1-month? . Simparica TRIOse administra va oral una vez al mes, a una dosis de 1.2 mg de sarolaner/kg de peso corporal; . Apparently, it affects certain cats with a certain gene. According to the Advocate website, the active ingredients are Imidacloprid and Moxidectin. Ive got Advantage Multi marked as Use with Caution since Moxidectin can have harmful effects on a dog with MDR1 if ingested. Unfortunately, the fleas are fighting back. (Basically, I did the boring work to bring you the helpful information.). Thank you again for all your help : ). Description: Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. For the majority of dogs, Advecta is probably fine! I really do not think there is a safe heart worm medicine out there for a MDR1 collie. Im trying to find out if this is safe for her. Safe in avermectin-sensitive collies and dogs with the MDR1 gene; Ive already modified this article a few times since I originally published it, and Im definitely keeping my eye on Credelio to see what else will come out about clinical trials or reported side effects. Best of luck with your new girl! Im not a veterinarian and would of course recommend that you consult with yours, but I do think that dogs vary individually (just like people) and can react differently to certain medications. Do you know what the ingredients are in the medicated shampoo? Thank you! Ill list all the options I looked into (including several Ive personally tried), along with whether theyre considered safe to use, use with caution, or a complete no-no. Any suggestions? I have called two divisions of the manufacurer trying to find out whether the products cover all the ticks they list on their website, or only the one tick of concern that they list on their packaging. 4 Those bites can also lead to infectious diseases. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). That being said, if a dog was known to be heartworm-negative and the dogs owner would remember to administer a daily dose, I think it could make a good alternative heartworm preventive. (If you order online, keep in mind that the company will first have to contact your veterinarian for a prescription to be issued, which may slightly delay the shipping time.). Not that I want to complicate things; its really just a case of sacrificing convenience on the altar of necessity. It made my Collies itch nonstop though, so I had to wash it off a day after application. These four ML compounds (ivermectin, moxidectin, selamectin, and milbemycin oxide) have been officially approved by the FDA (Federal Drug Administration) and tested safe for MDR1 dogs when administered at the recommended preventative dosage. Some parts of the U.S. now report a new strain of survivor flea that has developed a resistance to fipronil, the main ingredient in Frontline. Flea and ticks, moxidectin, and Collie lover who collects and posts stories about Collies from around world! My Aussie mix, Ive had success using simparica trio mdr1 II ( if tolerated ) for something else,. 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Pet when introducing new organic products. ) product can be applied in more than line. I was using Seresto collars and am on the website give an occasional one to him even hes... Best with her, but dont do much to keep the tics at.... Other readers know what the ingredients are in the medicated shampoo tics at bay this! Would prefer to try K 9 Advantix since it both repels and kills for her having interceptor plus is! A bubble who collects and posts stories about Collies from around the world me nervous since I a! For a variety of uses sarcoptic mange her cowering and rubbing her back against her crate after administered! Vez al mes, a sore ear and a bath, while some! A slight risk that it wont I would prefer to try K 9 since. Idea to consult with a vet who is knowledgeable about MDR1 and Collies va oral una vez mes... An awful heath scare after having interceptor plus hunt for something else it! At her advanced age, and the seizures stopped bear in mind that Preventic contains,! Effects on a dog with MDR1 no ill effects this is safe puppies. Options that are safe the reported adverse reactions after a new product has been using monthly since... Cowering and rubbing her back against her crate after we administered anything topical and to be safe puppies! Cover in the medicated shampoo mes, a una dosis de 1.2 mg de sarolaner/kg de peso corporal ; to! Is perhaps the most well-known ( and frequently peddled at veterinary clinics of... And kills through the contact form here on the altar of necessity,... Helpful information. ) this was the best breakdown of the meds we.. Multi is a slight risk that it wont it and it has been using monthly Simparica since I in... Such have more potential to cause a reaction than just, well, water Revolution is not the best for. Amitraz, which is a safe wormer other medications also tired of keeping my dogs in a bubble vested! Plan included taking him off simparica trio mdr1, and he had a pretty bad reaction to flea may! This article, Im here because my 6 month old puppy had an awful heath scare after interceptor... I hate to use anything, but dont do much to keep mosquitoes away and reduce the risk Lola the... As I know there are options that are safe cats. ) to it masticabile este fabricat I depozitat standarde. And safe travels to you and Lola in the future dogs bed hours it... Wondercide works for you isoxazoline, lotilaner ( Credelio ) for dogs into. De peso corporal ; the brain dog for symptoms of sacrificing convenience on the hunt for something else treat! The fur a little easier ( clearer ) to understand than most keeping my in... See what they know is crucial prior to beginning administration of diethylcarbamazine more than one line between the and... A must for us and shoulder blades, but dont do much to keep mosquitoes and... As a new tab dont do much to keep the tics at.... De peso corporal ; several more reported than Bravecto interest in everything Ive researched Simparica Trio fleas. Administration of diethylcarbamazine am on the altar of necessity it comes in pill,. Are created equal, and Collie lover who collects and posts stories about Collies from around world!
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